Origins of MatrixylTM 3000
Matrixyl refers to a family of peptides that not only protect the skin’s extracellular matrix but also activate its self-repair and renewal processes. The very first generation already set new standards in anti-aging skincare at the end of the 1990s. Optimized developments such as Matrixyl™ 3000 were designed to target specific mechanisms within the skin (Lintner et al., 2020).
Mode of Action and Peptide Components in Detail
Matrixyl acts as a biomimetic signal peptide (Jariwala et al., 2022). It mimics natural fragments that are generated during injury or collagen breakdown, which normally signal the skin: “Repair yourself, rebuild your matrix!” Matrixyl stimulates exactly this regenerative process – effectively and sustainably.
Palmitoyl Tripeptide-1 (Pal-GHK)
- Stimulates the neogenesis of collagen types I, III, and IV.
- Enhances the production of glycosaminoglycans such as hyaluronic acid – essential for hydration and elasticity.
Palmitoyl Tetrapeptide-7
- Reduces the release of pro-inflammatory cytokines triggered by UV exposure or skin aging.
- Decreases the formation of AGEs (Advanced Glycation Endproducts), which stiffen and damage collagen.
- Has a soothing effect and helps visibly reduce redness. (Schagen, 2017; Veiga et al., 2023)
Proven Effects – Long-Term and Cumulative
In-vivo studies demonstrate that MatrixylTM 3000 can reduce wrinkle depth by up to 45% and improve skin elasticity by around 20% after just two months of use (Kachooeian et al., 2022; Lintner et al., 2020). Its efficacy builds up gradually and is cumulative: unlike hyaluronic fillers, there is no immediate effect, but rather a sustainable structural improvement.
Moreover, Matrixyl is considered highly well-tolerated, even on sensitive skin (Schagen, 2017), and gives the complexion not only a visibly smoother appearance but also supports regeneration on the cellular level.
To improve skin density and firmness and to prevent loss of volume, especially in the cheek contour or in the case of stretch marks. The peptide complex Matrixyl and vitamin C strengthen the collagen structure and support the build-up of skin tissue. A hyaluronic acid complex and the protein Vegeseryl bind long-lasting deep moisture for plump, elastic skin.Blog: Matrixyl - High-tech peptides for true skin regenerationWhy does cross-linked hyaluronic acid last longer?
Content: 20 ml (€599.50 / 100 ml)
Fast-absorbing anti-aging cream for day and night. Controls excess shine and leaves a matte finish. The DMS base strengthens the skin barrier, while hyaluronic acid provides intensive moisture. The Matrixyl peptide complex promotes collagen synthesis, provides a firming, smoothing effect and reduces the signs of skin aging. Ideal for oily and combination skin.Blog: What is the DMS? – Strong skin barrier, No "washout effect"!Matrixyl - High-tech peptides for true skin regeneration
Content: 50 ml (€123.80 / 100 ml)
Daily anti-aging care with UV filter for all skin types, especially for normal and combination skin. The DMS cream base and vitamin C strengthen the skin barrier, while hyaluronic acid provides intensive, long-lasting moisture. The amino acids lysine and proline promote skin vitality and, in combination with the collagen-stimulating peptide complex Matrixyl, ensure supple and plump skin.Blog: What is the DMS? – Strong skin barrier, No "washout effect"!Matrixyl - High-tech peptides for true skin regeneration
Content: 50 ml (€139.80 / 100 ml)
The lipid content of this anti-aging day cream is specially adapted to dry skin. The DMS cream base and vitamin C strengthen the skin barrier, while hyaluronic acid provides intensive, long-lasting moisture. The collagen-stimulating peptide complex Matrixyl provides firming, smoothing effects, while the amino acids lysine and proline promote skin health. With UV filter.Blog: What is the DMS? – Strong skin barrier, No "washout effect"!Matrixyl - High-tech peptides for true skin regeneration
Content: 50 ml (€139.80 / 100 ml)
Effective firming for the eye area. The Matrixyl peptide complex supports collagen synthesis, while the phyto-tensors in SymLift® smooth and tighten fine lines. The DMS cream base strengthens the skin barrier, while panthenol soothes and relieves irritation. The formulation provides intensive, long-lasting hydration without cream migration - ideal for all skin types.Blog: What is the DMS? – Strong skin barrier, No "washout effect"!Matrixyl - High-tech peptides for true skin regenerationWhy does cross-linked hyaluronic acid last longer?
Content: 30 ml (€333.00 / 100 ml)
Soothes and regenerates scarred skin. The Matrixyl peptide complex promotes collagen synthesis to strengthen the tissue, while microsilver keeps the skin hygienically clean and prevents irritation. A complex of four different hyaluronic acid molecule sizes ensures optimum hydration. The overall effect promotes cell renewal in a variety of ways. Suitable for all skin types and body areas.Blog:Matrixyl - High-tech peptides for true skin regeneration
Content: 30 ml (€266.33 / 100 ml)
For firmness and vitality of the fine skin on the neck and décolleté. The active ingredient complex Regestril™ strengthens the tissue structure and visibly reduces fine lines on the neck and décolleté. A highly effective hyaluronic acid combination provides intensive moisture, while the DMS cream base protects the skin and gives it suppleness and a natural glow.Blog: What is the DMS? – Strong skin barrier, No "washout effect"!Matrixyl - High-tech peptides for true skin regenerationWhy does cross-linked hyaluronic acid last longer?
Content: 50 ml (€131.80 / 100 ml)
Jariwala, N., Vasudevan, S., & Kuppusamy, G. (2022). Matrikines as mediators of tissue remodelling. Matrix Biology Plus, 14, 100103. https://doi.org/10.1016/j.mbplus.2022.100103
Kachooeian, M., Radvar, S., Khajehpour, H., & Mohammad-Beigi, H. (2022). A comparative in vivo investigation of Matrixyl (MTI) effect. Journal of Cosmetic Dermatology, 21(7), 2823–2830. https://doi.org/10.1111/jocd.15175
Lintner, K., Mas-Chamberlin, C., Mondon, P., Peschard, O., & Lamy, F. (2020). A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging. Journal of Cosmetic Dermatology, 19(12), 3330–3338. https://doi.org/10.1111/jocd.13722
Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16. https://doi.org/10.3390/cosmetics4020016
Veiga, E., Martins, A. M., Neves, J., & Sarmento, B. (2023). Anti-aging peptides for advanced skincare. Comptes Rendus Chimie, 26(S2), 1–20. https://doi.org/10.5802/crchim.245